ANTI-FATIGUE EFFICACY OF CROCIN IN MICE VIA REGULATION OF NRF-2/HO-1 PATHWAY-MEDIATED OXIDATIVE STRESS
نویسندگان
چکیده
ABSTRACT Introduction: Fatigue is a manifestation of sub-health status, which causes serious negative effects in daily life. The antioxidant properties crocin have been widely investigated many diseases. However, no correlation between and fatigue was reported. Objective: To verify the anti-fatigue efficacy swimming-induced exhaustive time. Materials Methods: In this study, mice were treated with for 28 days to assess its efficacy. Exhaustive time, fatigue-relevant biochemical indices, inflammatory cytokines, energy metabolism indicators, oxidation parameters, NRF-2/HO-1 pathway analyzed explore evidence high-intensity exercise. Results: Our research indicated that dramatically extended strenuous swimming, clearly eliminated BLA SUN maintain internal environment homeostasis, while it markedly improved glycogen concentrations muscles liver promote reserves. Moreover, visibly reaction, as represented by reductions TNF-a IL-6, promoting endurance capacity. muscles, noticeably enhanced SDH Na+K+-ATP activities improve swimming. Lastly, SOD CAT via defend against oxidative stress-induced fatigue. Conclusions: Crocin provides resistance can be developed into nutriments. Evidence level II; Comparative prospective study.
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ژورنال
عنوان ژورنال: Revista Brasileira De Medicina Do Esporte
سال: 2022
ISSN: ['1517-8692', '1806-9940']
DOI: https://doi.org/10.1590/1517-8692202228042020_0030